Acid ceramidase (Ac) is part of the sphingolipid metabolism and responsible for the degradation of ceramide.As bioactive molecule, ceramide is involved in the regulation of many cellular processes.However, the impact of cell-intrinsic Ac activity and ceramide on the course of Plasmodium infection remains elusive.Here, we Wine Tumbler use Ac-deficie
We extend the classical compartmental frameworks Gift Card for susceptible-infected-susceptible (SIS) and susceptible-infected-recovered (SIR) systems to include an exposed/latent class or a chronic class of infection.Using a suite of stochastic continuous-time Markov chain models we examine the impact of latent and chronic infection on the mean ti
Abstract Background Activated T cells play a pivotal role in rheumatoid arthritis (RA) pathogenesis, and imaging of activated T cells may provide a non-invasive tool for RA detection.Here, we first developed an optical probe targeting human inducible T cell co-stimulator (ICOS) and tested its capacity in RA diagnosis by capturing ICOS+ activated T
Abstract The basic aim of this work is to compile the theoretical basis of ACI 440.2R: 2008 [1] with the NBR 6118: 2014 [2] in order to take into account the concepts of the Brazilian standard in flexural sizing of reinforced beams with CFRP (Carbon Fiber Reinforced Polymer).The contribution of the Brazilian Sashimi Knives standard is given particu
Brain Machine Interfaces (BMIs) are promising technologies to rehabilitate the function of upper limbs in severely paralyzed patients.We succeeded in AGE-DEFYING DAY CREME developing a BMI prosthetic arm for a monkey implanted with electrocorticogram (ECoG) electrodes and trained in a reaching task.It had stability in preventing the misclassificati